Dehydroascorbate transport across the plasma membrane Authored: D'Eustachio, P, 2007-07-05 13:27:27 Pubmed10862609 Pubmed9228080 Reactome Database ID Release 43198818 Reactome, http://www.reactome.org ReactomeREACT_11168 The uptake of extracellular dehydroascorbate into the cytosol is mediated by GLUT1 and GLUT3 associated with the plasma membrane (Rumsey et al. 1997, 2000). This process may play a significant role in ascorbate utilization in the central nervous system (Agus et al. 1997). The process is efficiently competitively inhibited by glucose, leading to the suggestion that inhibited dehydroascorbate uptake may contribute to the pathology of diabetes (Liang et al. 2001; Rumsey et al. 2000). dehydroascorbate [extracellular] => dehydroascorbate [cytosol]