Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP ADP-ribose + H2O => AMP + D-ribose 5-phosphate (cytosolic) Authored: D'Eustachio, P, 2012-07-06 Cytosolic NUDT5 dimer (ADP-ribose pyrophosphatase) catalyzes the hydrolysis of ADP-ribose to form AMP and D-ribose 5-phosphate. Each NUDT5 subunit is associated with three magnesium ions (Zha et al. 2006, 2008). NUDT5 also catalyzes the hydrolysis of 8-oxo-dGTP but with a strongly alkaline pH optimum (Ito et al. 2011) so the physiological relevance of this reaction is unclear and it is not annotated here. EC Number: 3.6.1.13 Edited: D'Eustachio, P, 2012-07-06 Pubmed17052728 Pubmed18462755 Pubmed21389046 Reactome Database ID Release 432393939 Reactome, http://www.reactome.org ReactomeREACT_150191 Reviewed: Ito, Riyoko, 2012-10-05