Phosphopantetheine conjugation of the ACP domain of FAS Authored: D'Eustachio, P, 2007-07-09 22:03:12 CoA-SH + FAS apoenzyme => adenosine 3',5'-bisphosphate + FAS holoenzyme Cytosolic AASDHPPT (alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase) catalyzes the transfer of a phosphopantetheine moiety from coenzyme A to serine 2156 within the ACP domain of FAS (fatty acyl synthase). Only a single human enzyme with phosphopantetheinyl transferase activity has been identified, and its broad substrate specificity suggests that it may be responsible as well for the postranslational modification of enzymes of lysine catabolism (Joshi et al. 2003; Praphanphoj et al. 2001). EC Number: 2.7.8.7 Pubmed11286508 Pubmed12815048 Reactome Database ID Release 43199202 Reactome, http://www.reactome.org ReactomeREACT_11175