CoA transport across the inner mitochondrial membrane Authored: D'Eustachio, P, 2007-07-09 22:03:12 Pubmed11158296 Pubmed17242360 Reactome Database ID Release 43199216 Reactome, http://www.reactome.org ReactomeREACT_11209 SLC25A16, associated with the inner mitochondrial membrane, mediates the transport of CoA (coenzyme A) into the mitochondrial matrix. Evidence for this event is indirect. The protein has the sequence motifs expected for a transport protein, and yeast cells deficient in its homologue, Leu5p, fail to accumulate mitochondrial CoA and can be rescued by expression of SLC25A16. At the same time, neither the yeast nor the human protein has been shown directly to function as a transporter (Prohl et al. 2001; Leonardi et al. 2007).