Pantothenate is phosphorylated [PANK2] Authored: Jassal, B, 2007-04-24 08:38:46 EC Number: 2.7.1.33 Pantothenate kinase 2 catalyzes the reaction of ATP and pantothenate to form ADP and phosphopantothenate. While pantothenate kinase 2 co-purifies with mitocondria, its precise location within the mitochondrion has not been established (Hortnagel et al. 2003; Johnson et al. 2004). Recent work by Leonardi et al. (2007) supports a model in which the enzyme is located in the intermembrane space, hence freely accessible to small molecules from the cytosol.Pantothenate is phosphorylated by pantothenate kinase (PANK). Deficiencies in PANK2 cause a progressive neurodegenerative disorder associated with iron accumulation in the brain, but the relationship between disease symptoms and pantothenate metabolism remains unclear (Zhou et al. 2001; Zhang et al. 2006). Pubmed11479594 Pubmed12554685 Pubmed15105273 Pubmed16272150 Pubmed17242360 Reactome Database ID Release 43196857 Reactome, http://www.reactome.org ReactomeREACT_11197