Fumarate + H2O <=> (S)-Malate EC Number: 4.2.1.2 Mitochondrial fumarate hydratase catalyzes the reversible reaction of fumarate and water to form malate, the seventh step of the TCA cycle (Bourgeron et al. 1994). Unpublished crystallographic data indicate that the protein is a tetramer (PDB 3E04). Pubmed8200987 Reactome Database ID Release 4370982 Reactome, http://www.reactome.org ReactomeREACT_1656