(R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate ADHFE1 catalyzes the reversible reaction of (R)-2-hydroxyglutarate and succinate semialdehyde to form 2-oxoglutarate and 4-hydroxybutyrate (Struys et al. 2005). The localization of human ADHFE1 to the mitochondrial matrix is inferred from the location determined experimentally for its rat homolog (Kaufman et al. 1988). Authored: D'Eustachio, P, 2010-06-25 EC Number: 1.1.99.24 Edited: D'Eustachio, P, 2010-06-25 Pubmed16435184 Pubmed3182820 Reactome Database ID Release 43880002 Reactome, http://www.reactome.org ReactomeREACT_25041 Reviewed: Jassal, B, 2010-11-09 Reviewed: Rush, MG, 2011-01-31