AMP + ATP <=> ADP + ADP [AK2] EC Number: 2.7.4.3 Mitochondrial adenylate kinase 2 (AK2) catalyzes the reaction of AMP and ATP to form two molecules of ADP (Hamade et al. 1982). Localization of AK2 specifically to the mitochondrial intermembrane space is inferred from studies of the homologous rat enzyme (Criss 1970). Pubmed5484814 Pubmed6182143 Reactome Database ID Release 43110145 Reactome, http://www.reactome.org ReactomeREACT_390 has a Stoichiometric coefficient of 2