IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS] Authored: D'Eustachio, P, 2004-02-19 09:47:00 EC Number: 6.3.4.4 Edited: D'Eustachio, P, 0000-00-00 00:00:00 Pubmed15786719 Pubmed1592113 Reactome Database ID Release 43111524 Reactome, http://www.reactome.org ReactomeREACT_1719 Two isoforms of adenylosuccinate synthetase, ADSS and ADSSL1, catalyze the reaction of IMP, aspartate, and GTP to form adenylosuccinate, GDP, and orthophosphate (Powell et al. 1992; Sun et al. 2005). ADSS is a homotetramer (unpublished crystallographic data - PDB 2V40) and ADSSL1 is inferred to be a tetramer likewise. inosine 5'-monophosphate + L-aspartate + GTP => adenylosuccinate + guanosine 5'-diphosphate + orthophosphate