AICAR + 10-Formyl-THF => FAICAR + THF 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate => 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) + tetrahydrofolate Authored: D'Eustachio, P, 2004-02-12 14:16:00 EC Number: 2.1.2.3 Edited: D'Eustachio, P, Jassal, B, 0000-00-00 00:00:00 Pubmed11096114 Pubmed18388293 Pubmed8567683 Reactome Database ID Release 4373798 Reactome, http://www.reactome.org ReactomeREACT_812 The irreversible transfer of a formyl group to 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR), to yield 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR), is catalyzed by the phosphoribosylaminoimidazolecarboxamide formyltransferase activity of the bifunctional 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase enzyme. This cytosolic protein occurs primarily as a dimer (Rayl et al. 1996; Vergis et al. 2001) and may further associate with other enzymes of de novo IMP biosynthesis under some metabolic conditions (An et al. 2008).