5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi 5-phosphoribosylamine + glycine + ATP => 5-phosphoribosylglycinamide (GAR) + ADP + orthophosphate Authored: D'Eustachio, P, 2004-02-12 15:28:00 EC Number: 6.3.4.13 Edited: D'Eustachio, P, Jassal, B, 0000-00-00 00:00:00 Pubmed11381136 Pubmed18388293 Pubmed2147474 Reactome Database ID Release 4373814 Reactome, http://www.reactome.org ReactomeREACT_285 The synthesis of cytosolic 5-phosphoribosylglycinamide from 5-phosphoribosylamine and glycine, accompanied by the conversion of ATP to ADP and orthophosphate, is catalyzed by the phosphoribosylglycinamide synthetase domain of the trifunctional protein, "phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase" (GART) (Aimi et al. 1990). The active form of the protein is cytosolic (Gooljarsingh et al. 2001; An et al. 2008).