GMP + NADPH + H+ => IMP + NADP+ + NH4+ [GMPR,GMPR2] Authored: D'Eustachio, P, 2010-02-17 Cytosolic GMP reductase (GMPR) catalyzes the reaction of GMP and NADPH + H+ to yield IMP and NADP+ + NH4+ (Spector et al. 1979; Deng et al. 2002). Two GMPR proteins have been identified, GMPR and GMPR2. Both proteins form homotetramers (GMPR - unpublished crstallographic data PDB 2BLE; GMPR2 - Li et al. 2006). EC Number: 1.7.1.7 Edited: D'Eustachio, P, 2010-02-18 Pubmed12009299 Pubmed16359702 Pubmed218932 Reactome Database ID Release 43514604 Reactome, http://www.reactome.org ReactomeREACT_21383 Reviewed: Graves, L, Rush, MG, 0000-00-00 00:00:00