Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B Arachidonate 15-lipoxygenase (ALOX15) (Gulliksson et al. 2007, Kuhn et al. 1993, Izumi et al. 1991) and arachidonate 15-lipoxygenase B (ALOX15B) (Tang et al. 2002, Wecksler et al. 2008) are lipid peroxidising enzymes mainly expressed in airway epithelial cells, eosinophils, reticulocytes and in macrophages. They insert molecular oxygen at C-6 from the omega-end of arachidonic acid with formation of the unstable intermediate 15S-hydroperoxyeicosatetraenoic acid (15S-HpETE) which can be further converted, enzymatically or non-enzymatically, to 15S-hydroxyeicosatetraenoic acid (15S-HETE). Authored: Williams, MG, 2012-02-24 EC Number: 1.13.11.33 Edited: Williams, MG, 2012-02-24 Pubmed11839751 Pubmed1662607 Pubmed17662651 Pubmed18570379 Pubmed8334154 Reactome Database ID Release 432162002 Reactome, http://www.reactome.org ReactomeREACT_150130 Reviewed: Rush, MG, 2012-11-10