12S-HpETE is reduced to 12S-HETE by GPX1/2/4 Authored: Williams, MG, 2012-02-24 EC Number: 1.11.1.9 Edited: Williams, MG, 2012-02-24 Glutathione peroxidase 1 (GPX1) (Bryant et al. 1982, Sutherland et al. 2001), 2 (GPX2) (Chu et al. 1993), and 4 (Bryant et al. 1982, Sutherland et al. 2001) are involved in converting 12S-hydroperoxy-eicosatetraenoic acid (12S-HpETE) to 12S-hydro-eicosatetraenoic acid (12S-HETE). GPXs are selenoenzymes that are responsible for reducing the cellular peroxide. Cellular GPXs compete with hepoxilins A3 (HXA3) synthase for 12S-HpETE as substrate either to produce 12S-HETE or to convert to HXA3, respectively. Pubmed11115402 Pubmed6816802 Pubmed8428933 Reactome Database ID Release 432161999 Reactome, http://www.reactome.org ReactomeREACT_150391 Reviewed: Rush, MG, 2012-11-10 has a Stoichiometric coefficient of 2