HXA3/B3 Arachidonic acid is converted to HXA3/B3 by ALOX12 Arachidonate 12-lipoxygenase, 12S-type (ALOX12) converts arachidonic acid to both hepoxilin A3 (HXA3) and B3 (HXB3). They both incorporate an epoxide across the C-11 and C-12 double bond, as well as an additional hydroxyl moiety with HXA3 having a C-8 hydroxyl, whereas the HXB3 hydroxyl occurs at C-10 (Sutherland et al. 2001, Nigam et al. 2004). Authored: Williams, MG, 2012-02-24 Edited: Williams, MG, 2012-02-24 Pubmed11115402 Pubmed15123652 Reactome Database ID Release 432161794 Reactome, http://www.reactome.org ReactomeREACT_150129 Reviewed: Rush, MG, 2012-11-10