Steryl sulfatase hydrolyses sulfate from steroid sulfates Authored: Jassal, B, 2011-09-27 EC Number: 3.1.6.2 Edited: Jassal, B, 2011-09-27 Pubmed1539590 Pubmed1606923 Pubmed2668275 Pubmed2953589 Pubmed6417417 Pubmed9252398 Reactome Database ID Release 431606839 Reactome, http://www.reactome.org ReactomeREACT_115686 Reviewed: Stephan, R, 2011-10-31 Steryl sulfatase (formerly arylsulfatase C, ARSC) hydrolyses sulfate from steroid sulfates (Noel et al. 1983, Vaccaro et al. 1987, Suzuki et al. 1992). It is located on the ER membrane (Stein et al. 1989) and functions as a homodimer, using calcium as a cofactor. Defects in STS are the cause of ichthyosis X-linked (IXL) (MIM:308100), a keratinisation disorder (Basler et al. 1992, Alperin & Shapiro 1997).