Inhibition of Adenylate Cyclase by G-beta:G-gamma Adenylyl cyclases V and VI are the particular adenylyl cyclases present in beta cells of the human pancreas. The G-protein beta-gamma complex interacts with adenylyl cyclases via protein-protein interactions with the C1 and C2 cytoplasmic loops of adenylyl cyclase. The interaction may produce either stimulation or inhibition of the adenylyl cyclase depending on the particular adenylyl cyclase. In the case of adenylyl cyclases V and VI the interaction inhibits cyclase activity. Authored: May, B, 2009-05-27 03:41:50 Edited: May, B, 2009-05-27 03:41:50 Pubmed10449730 Pubmed14514350 Pubmed17900700 Pubmed7641683 Pubmed8099279 Pubmed8997178 Pubmed9707174 Pubmed9920805 Reactome Database ID Release 43400097 Reactome, http://www.reactome.org ReactomeREACT_18261 Reviewed: D'Eustachio, P, 2009-06-02 00:48:17 Adenylate Cyclase V or VI G-beta:G-gamma (candidates) Adenylate cyclase type V or VI: G-protein beta gamma Complex