Activation of Gq by Muscarinic Acetylcholine Receptor M3 Authored: May, B, 2009-05-28 03:44:04 Edited: May, B, 2009-05-28 03:44:04 Pubmed11588141 Pubmed12194018 Pubmed16753580 Pubmed16871065 Pubmed17900700 Pubmed17919190 Pubmed18383439 Pubmed8190105 Reactome Database ID Release 43399995 Reactome, http://www.reactome.org ReactomeREACT_18309 Reviewed: Gillespie, ME, 2009-06-02 00:56:21 The binding of acetylcholine to the Muscarinic Acetylcholine Receptor M3 activates the heterotrimeric G protein, Gq, associated with the M3 receptor. Activation occurs through protein-protein interaction and results in the alpha subunit of Gq exchanging GDP for GTP (i.e releasing GDP and binding GTP). The 3 subunits of the G protein then dissociate into an alpha:GTP complex and a beta:gamma complex. G(q) alpha 11/14/15/Q:GDP:G beta:G gamma G(q) alpha 11/14/15/Q:G beta:G gamma