Dissociation of Gq alpha:GTP Complex from G beta:G gamma Complex Authored: May, B, 2009-05-28 03:44:04 Edited: May, B, 2009-05-28 03:44:04 In the non-activated state heterotrimeric G proteins exist at membranes as heterotrimeric complexes of alpha, beta, and gamma subunits, with the alpha subunit bound to GDP. Upon activation by a receptor coupled to the heterotrimer, exchange of GDP for GTP by the Gq alpha subunit causes the alpha subunit to lose affinity for the beta and gamma subunits. The alpha subunit with bound GTP then dissociates from the beta and gamma subunits. Pubmed15448129 Pubmed16242307 Pubmed16339447 Pubmed17095603 Pubmed17962409 Pubmed19212142 Reactome Database ID Release 43400027 Reactome, http://www.reactome.org ReactomeREACT_18316 Reviewed: Gillespie, ME, 2009-06-02 00:56:21 G beta:G gamma G(q) alpha 11/14/15/Q:GTP G(q) alpha 11/14/15/Q:G beta:G gamma