Activation of Phospholipase C Beta by Gq alpha Authored: May, B, 2009-05-28 03:44:04 Edited: May, B, 2009-05-28 03:44:04 Pubmed11588141 Pubmed17900700 Pubmed1846707 Reactome Database ID Release 43400023 Reactome, http://www.reactome.org ReactomeREACT_18418 Reviewed: Gillespie, ME, 2009-06-02 00:56:21 The Gq alpha:GTP complex activates Phospholipase C beta-1 through protein interaction (inferred from homologues in Bos taurus). The activation by Gq alpha is insensitive to pertussis toxin whilst activation of PLC beta by the G beta-gamma complex is sensitive to pertussis toxin. PLC beta 1/2/3 PLC beta1/2/3:G(q) alpha:GTP G(q) alpha 11/14/15/Q:GTP