NRAMP1 transports divalent metal ions across phagosomal membranes of macrophages Authored: Jassal, B, 2009-09-07 Edited: Jassal, B, 2009-08-21 Natural resistance-associated macrophage proteins (NRAMPs) regulates macrophage activation for antimicrobial activity against intracellular pathogens. They do this by mediating metal ion transport across macrophage membranes and the subsequent use of these ions in the control of free radical formation.<br>The human gene SLC11A1 encodes NRAMP1 (Kishi F, 2004; Kishi F and Nobumoto M, 1995) which can utilize the protonmotive force to mediate divalent iron (Fe2+), zinc (Zn2+) and manganese (Mn2+) influx to or efflux from phagosomes. Pubmed7980580 Pubmed8537108 Reactome Database ID Release 43435171 Reactome, http://www.reactome.org ReactomeREACT_20522 Reviewed: He, L, 2009-11-12 has a Stoichiometric coefficient of 2 Divalent metals transported by NRAMP1 Divalent metals transported by NRAMP1