Adenylate cyclase produces cAMP Adenylate cyclase is responsive to calcium and calmodulin and produces cAMP. One important physiological role for Calmodulin is the regulation of adenylylcyclases. Four of the ten known adenylylcyclases are calcium sensitive, in particular type 8 (AC8). Authored: Le Novere, N, Jassal, B, 2004-03-31 12:22:05 Edited: Jassal, B, 2008-11-06 10:17:49 Pubmed10075700 Pubmed16613843 Reactome Database ID Release 43111930 Reactome, http://www.reactome.org ReactomeREACT_1963 Reviewed: Castagnoli, L, 2008-11-06 12:55:54