Pro-EGF is cleaved to form mature EGF Authored: Castagnoli, L, 2006-10-10 13:09:34 EC Number: 3.4.24 Ligands of the epidermal growth factor receptor (EGFR) are shed from the plasma membrane by metalloproteases. Identification of the sheddases for EGFR ligands using mouse embryonic cells lacking candidate sheddases (a disintegrin and metalloprotease; ADAM) has revealed that ADAM10, -12 and -17 are the sheddases of the EGFR ligands in response to various shedding stimulants such as GPCR agonists, growth factors, cytokines, osmotic stress, wounding and phorbol ester. Among the EGFR ligands, heparin-binding EGF-like growth factor (HB-EGF), EGF and TGF-alpha are the best characterized. Reactome Database ID Release 43177946 Reactome, http://www.reactome.org ReactomeREACT_9423 Reviewed: Muthuswamy, S, 2007-02-16 20:08:05