Binding of M1 to vRNP Authored: Bortz, E, Garcia-Sastre, A, 2007-02-12 19:39:05 M1 protein binds to viral RNP through its C-terminal domain (Baudin, 2001). The influenza M1 protein accumulates in the infected cell nucleus through a nuclear localization signal (NLS) RKLKR (residues 101-105) in its N-terminus (Ye, 1999). A host cell protein, HSP70, is thought to inhibit M1 binding at nonpermissive temperatures (Hirayama et al., 2004). Pubmed10438836 Pubmed10644350 Pubmed11222100 Pubmed11531417 Pubmed12490406 Pubmed14722281 Reactome Database ID Release 43192746 Reactome, http://www.reactome.org ReactomeREACT_9407 Reviewed: Squires, B, 2007-02-12 19:39:22 vRNP:M1 for Export vRNP destined for Export