Palmitoylation of cysteine residues on HA in the cis-Golgi network Authored: Steel, J, 2007-04-30 20:49:24 GENE ONTOLOGYGO:0019082 Pubmed1297175 Pubmed1433532 Pubmed16227287 Pubmed1664239 Pubmed1871979 Pubmed1901916 Pubmed2371783 Pubmed8262238 Pubmed8627657 Pubmed8761467 Pubmed9791024 Reactome Database ID Release 43168858 Reactome, http://www.reactome.org ReactomeREACT_6187 Reviewed: Squires, B, Rush, MG, 2007-04-30 20:48:45 The hemagglutinin of influenza virus is palmitoylated with long-chain fatty acids.<br>Palmitoylation of HA is believed to occur in the cis golgi network (Veit 1993), shortly after trimerisation of the molecule, and before cleavage of the HA into HA1 and HA2. HA is palmitoylated through thioester linkages at three cysteine residues located in the cytoplasmic domain and at the carboxy-terminal end of the transmembrane region. Lack of acylation has no obvious influence on the biological activities of HA. Glycosylated and folded HA trimer Glycosylated, palmitylated and folded HA trimer