Secretion of Glucagon-like Peptide 1 from Intestinal L Cells Authored: May, B, 2009-05-18 21:31:59 Edited: May, B, 2009-09-09 Pubmed11564718 Pubmed12540594 Pubmed12810581 Pubmed14719035 Pubmed15619630 Pubmed16219666 Pubmed17065399 Pubmed17681422 Pubmed18519800 Pubmed19001044 Reactome Database ID Release 43383313 Reactome, http://www.reactome.org ReactomeREACT_24006 Reviewed: Bloom, SR, 2010-06-24 Secretion of GLP-1 from intestinal L-cells is dependent on a rise in cytosolic calcium which, in turn, is stimulated by glucose (requires the GLUT2 glucose transporter), fatty acids (especially monounsaturated fatty acids, requires the GPR120 and GPR40 receptors), insulin, leptin, gastrin-releasing peptide, cholinergic transmitters (requires M1 and M2 muscarinic receptors), amino acids (requires mitogen activated protein kinase pathway), beta-adrenergic transmitters, and peptidergic transmitters. The exact mechanisms controlling secretion have not been elucidated. GLP-1 GLP-1