Closing of Inward Rectifying, ATP-sensitive Potassium Channels (KATP channels) ATP-sensitive potassium channels (KATP channels) bind ATP and close. The KATP channels in the beta cell are inward rectifying (allowing potassium ions to pass out the cell) and are partially responsible for maintaining the resting potential of the cell, about -70 mV. Closure of the KATP channels causes a depolarization (a reduction in the voltage differential) across the plasma membrane. Authored: May, B, 2008-04-15 08:41:29 Edited: D'Eustachio, P, 2009-03-06 11:49:32 Edited: May, B, 2009-02-12 22:40:35 Pubmed10194514 Pubmed10206966 Pubmed10866047 Pubmed10868950 Pubmed11078440 Pubmed16332676 Pubmed16513675 Pubmed16556766 Pubmed17021801 Pubmed17380317 Pubmed17919183 Pubmed18346985 Pubmed18596924 Pubmed19587354 Reactome Database ID Release 43265682 Reactome, http://www.reactome.org ReactomeREACT_16883 Reviewed: Gillespie, ME, 2009-06-02 00:59:01 has a Stoichiometric coefficient of 4 Inward Rectifying Potassium Channel (open) Inward Rectifying Potassium Channel (closed)