Activation of Gq by Fatty Acid Receptor 1: Fatty Acid Complex Authored: May, B, 2009-06-08 Edited: May, B, 2009-06-08 FFAR1 (GPR40) is a G-protein coupled receptor. Based on studies with inhibitors of G proteins such as pertussis toxin FFAR1 is believed to signal through Gq/11. Binding of free fatty acids by FFAR1 activates the heterotrimeric Gq complex, which then activates Phospholipase C. From experiments in knockout mice it is estimated that signaling through FFAR1 is responsible for about 50% of the augmentation of insulin secretion produced by free fatty acids. The rest of the augmentation is due to metabolism of the free fatty acids within the pancreatic beta cell. Pubmed12496284 Pubmed15914509 Pubmed16081037 Pubmed17101212 Pubmed17130640 Pubmed17395749 Pubmed18606873 Pubmed18827341 Pubmed19398560 Reactome Database ID Release 43416530 Reactome, http://www.reactome.org ReactomeREACT_19346 Reviewed: Kebede, M, 2009-09-09 Reviewed: Madiraju, MS, 2009-10-02 Reviewed: Poitout, V, 2009-09-09 G(q) alpha 11/14/15/Q:GDP:G beta:G gamma G(q) alpha 11/14/15/Q:G beta:G gamma