Activation of G(s) by GLP-1R Authored: May, B, 2009-05-28 03:42:50 Edited: May, B, 2009-05-28 03:42:50 GLP-1R that has bound GLP-1 activates the alpha subunit of the heterotrimeric G-protein G(s) by protein-protein interaction between intracellular loop 3 of GLP-1R and G(s). The activation causes exchange of GDP for GTP by the alpha subunit of G(s). Pubmed15569269 Pubmed17306374 Pubmed17900700 Pubmed19859570 Pubmed8405712 Reactome Database ID Release 43381706 Reactome, http://www.reactome.org ReactomeREACT_18411 Reviewed: Calamita, G, 2010-07-15 Reviewed: Gillespie, ME, 2009-06-02 00:59:01 GLP-1: GLP-1R: Heterotrimeric G(s): GDP GLP-1: GLP-1R: Heterotrimeric G(s): GTP