G-protein alpha (s):GTP Rearrangement of the heterotrimeric G(s) complex Authored: May, B, 2009-05-28 03:44:04 Edited: May, B, 2009-05-28 03:44:04 Pubmed15569269 Pubmed17095603 Pubmed17306374 Pubmed17900700 Pubmed18577758 Pubmed8405712 Reactome Database ID Release 43422320 Reactome, http://www.reactome.org ReactomeREACT_18433 Reviewed: Beitz, E, 2010-06-24 Reviewed: Calamita, G, 2010-07-15 The binding of GTP by G(s) alpha causes the heterotrimeric G-protein complex to reorientate, exposing previously bound faces of the G(s) alpha:GTP complex and the G-beta: G-gamma complex. Unlike the case with Gi/o heterotrimers, Gs heterotrimers are not observed to significantly dissociate in living cells. G-alpha(s):GTP:G-beta:G-gamma G-beta:G-gamma (candidates)