G-protein alpha (s):GTP Activation of Adenylyl Cyclase by G(s):GTP Authored: May, B, 2009-05-28 03:42:50 By analogy with adenylyl cyclases I and II, adenylyl cyclase VIII is activated by G(s) alpha:GTP by protein-protein interaction between G(s) alpha and the C2 region of adenylyl cyclase VIII, forming a complex. Adenylyl cyclase VIII is present in beta cells of rat and is activated by both G(s) alpha:GTP and calcium:calmodulin, thus integrating signals from both GLP-1 via G(s) alpha and glucose via calcium. Human beta cells contain adenylyl cyclases V and VI, which are also activated by G(s) alpha:GTP, and may contain additional adenylyl cyclases. Edited: May, B, 2009-05-28 03:42:50 Pubmed13680124 Pubmed15569269 Pubmed17306374 Pubmed17900700 Pubmed9417641 Pubmed9920805 Reactome Database ID Release 43381704 Reactome, http://www.reactome.org ReactomeREACT_18332 Reviewed: Gillespie, ME, 2009-06-02 00:59:01 Adenylyl cyclase (pancreatic beta cell) Activated Adenylate Cyclase