Closing of Potassium voltage-gated channels by PKA Authored: May, B, 2009-05-28 03:42:50 Edited: May, B, 2009-05-28 03:42:50 Protein kinase A acts to antagonize voltage-gated potassium channels (Kv channels) by increasing the polarizing voltage required to open them. Maintenance of the Kv channels in the closed state prolongs depolarization and insulin secretion. The exact mechanism of the interaction between PKA and the Kv channels is unknown. Pubmed12475787 Pubmed14988243 Pubmed15569269 Pubmed15955806 Pubmed17306374 Reactome Database ID Release 43381713 Reactome, http://www.reactome.org ReactomeREACT_18269 Reviewed: Gillespie, ME, 2009-06-02 00:59:01 Potassium voltage-gated channels (beta cell, closed) Potassium voltage-gated channels (beta cell, open)