AKT1 phosphorylates eNOS Authored: Hemish, J, 2007-10-19 18:00:42 HSP90 serves as a scaffold to promote productive interaction between AKT1 and eNOS. Due to the proximity of these proteins once complexed with HSP90, AKT1 phosphorylates eNOS at Ser1177. When Ser1177 is phosphorylated, the level of NO production is elevated two- to three-fold above basal level. <br><br> Pubmed10376602 Pubmed10376603 Pubmed10469573 Reactome Database ID Release 43202111 Reactome, http://www.reactome.org ReactomeREACT_12415 Reviewed: Enikolopov, G, 2008-02-28 17:52:44 p-S1177-eNOS:CaM:HSP90:p-AKT1 eNOS:CaM:HSP90:p-AKT1