G-protein alpha (s):GTP G alpha (s) activates adenylate cyclase Authored: Jupe, S, 2009-03-09 10:38:40 Edited: May, B, 2009-08-11 G(s)-alpha:GTP binds to inactive adenylate cyclase, causing a conformational transition in adenylate cyclase exposing the catalytic site and activating it. Pubmed9417641 Reactome Database ID Release 43163617 Reactome, http://www.reactome.org ReactomeREACT_2219 Reviewed: Akkerman, JW, 2009-06-03 Adenylate cyclase (Mg2+ cofactor) Gs-activated adenylate cyclase