G-protein alpha (s):GTP Glucagon:GCGR mediates GTP-GDP exchange Authored: Gopinathrao, G, 2005-08-12 11:14:59 Edited: D'Eustachio, P, 2010-05-26 Reactome Database ID Release 43825631 Reactome, http://www.reactome.org ReactomeREACT_22110 Reviewed: D'Eustachio, P, 2010-05-25 The G(s)alpha G-beta G-gamma complex bound to glucagon, in the plasma membrane, releases a molecule of bound GDP, binds a molecule of GTP, and dissociates to yield a G(s)alpha:GTP complex and a G-beta:G-gamma dimer. G-beta:G-gamma dimer G-protein with G(s) alpha:GDP