PE is hydrolyzed to 1-acyl LPE by PLA2[2] At the endoplasmic reticulum (ER) membrane, phosphatidylethanolamine (PE) is hydrolyzed, and has one of its acyl chains cleaved off, by phospholipase A2 to form 1-acyl lysophosphatidylethanolamine (LPE). The phospholipases are either cytosolic phospholipase A2 alpha/beta/delta/epsilon/zeta (PLA2G(4A/B/D/E/F) (Ghosh et al. 2006, Yamashita et al. 2009, Yamashita et al. 1999, Ghomashchi et al. 2010), 85 kDa calcium-independent phospholipase A2 (PLA2G6) (Larsson et al. 1998, Ma et al. 1999, Larsson Forsell et al. 1999), group XVI phospholipase A2 (PLA2G16) (Duncan et al. 2008), or Phospholipase B-like 1 (PLBD1) (Xu et al. 2009). PLBD1 acts as a phospholipase A2 but in addition has the propensity to hydrolyze the lysophospholipid formed in its initial reaction. Authored: Williams, MG, 2011-09-14 EC Number: 3.1.1.4 Edited: Williams, MG, 2011-08-12 Pubmed10092647 Pubmed10336645 Pubmed15944408 Pubmed16617059 Pubmed18614531 Pubmed19019078 Pubmed19501189 Pubmed20705608 Pubmed9417066 Reactome Database ID Release 431482884 Reactome, http://www.reactome.org ReactomeREACT_121252