CL is hydrolyzed to MLCL by PLA2G6 (IM) At the inner mitochondrial membrane (IM), calcium-independent phospholipase A2 gamma (PLA2G6) hydrolyzes, removing one of the acyl chains, cardiolipin (CL) to form monolysocardiolipin (MLCL). This reaction is inferred from rats. PLA2G6 has also been characterized in humans (Larsson et al. 1998, Ma et al. 1999, Larsson Forsell et al. 1999). Authored: Williams, MG, 2011-09-14 EC Number: 3.1.1.4 Edited: Williams, MG, 2011-08-12 Pubmed10092647 Pubmed10336645 Pubmed9417066 Reactome Database ID Release 431482778 Reactome, http://www.reactome.org ReactomeREACT_120786