PC is hydrolyzed to 1-acyl LPC by PLA2[5] At the endoplasmic reticulum (ER) membrane, phosphatidylcholine (PC) is hydrolyzed and has one of its acyl chains cleaved off by a phospholipase A2 to form 1-acyl lysophosphatidylcholine (LPC). The phospholipases are either cytosolic phospholipase A2 alpha/beta/delta/zeta (PLA2G4A/B/D/F) (Ghomashchi et al. 2010, Clarke et al. 1991, Sharp et al. 1994, Song et al. 1999, Chiba et al. 2004), 85 kDa calcium-independent phospholipase A2 (PLA2G6) (Larsson et al. 1998, Ma et al. 1999, Larsson Forsell et al. 1999), group XVI phospholipase A2 (PLA2G16) (Duncan et al. 2008), or Phospholipase B-like 1 (PLBD1) (Xu et al. 2009). PLBD1 acts as a phospholipase A2 but in addition has the propensity to hydrolyze the lysophospholipid formed in its initial reaction. Authored: Williams, MG, 2011-09-14 EC Number: 3.1.1.4 Edited: Williams, MG, 2011-08-12 Pubmed10085124 Pubmed10092647 Pubmed10336645 Pubmed10358058 Pubmed14709560 Pubmed15944408 Pubmed18614531 Pubmed19019078 Pubmed1904318 Pubmed19501189 Pubmed20705608 Pubmed8083230 Pubmed9417066 Pubmed9705332 Reactome Database ID Release 431482856 Reactome, http://www.reactome.org ReactomeREACT_120953