PC is hydrolyzed to 1-acyl LPC by PLA2[6] At the endoplasmic reticulum (ER) membrane, phosphatidylcholine (PC) is hydrolyzed, and has one of its acyl chains cleaved off, by a membrane-associated phospholipase A2 to form 1-acyl lysophosphatidylcholine (LPC). The phospholipases are either phospholipase A2 group II alpha (PLA2G2A) (Seihamer et al. 1989, Singer et al. 2002), cytosolic phospholipase A2 group IV gamma (PLA2G4C) (Yamashita et al. 2005, Pickard et al. 1999, Ghomashchi et al. 2010, Yamashita et al. 2009), or calcium-independent phospholipase A2-gamma (PNPLA8) (Murakami et al. 2005, Underwood et al. 1998). Authored: Williams, MG, 2011-09-14 EC Number: 3.1.1.4 Edited: Williams, MG, 2011-08-12 Pubmed10085124 Pubmed12359733 Pubmed15695510 Pubmed15944408 Pubmed19501189 Pubmed20705608 Pubmed2925608 Pubmed9705332 Reactome Database ID Release 431482816 Reactome, http://www.reactome.org ReactomeREACT_121263