1-acyl LPC is hydrolyzed to GPCho by PLA2[8] At the endoplasmic reticulum (ER) membrane, 1-acyl lysophosphatidylcholine (LPC) is hydrolyzed to glycerophosphocholine (GPCho) by cytosolic phospholipase A2 alpha/beta/delta/epsilon/zeta (PLA2G4A/B/D/E/F) (Yamashita et al. 2005, Ghomashchi et al. 2010, Yamashita et al. 2009, Sharp et al. 1994) or by Phospholipase B1-like (PLBD1) (Xu et al. 2009). PLBD1 also acts as a phospholipase A2 but in addition has the propensity to hydrolyze the lysophospholipid formed in its initial reaction. Authored: Williams, MG, 2011-09-14 EC Number: 3.1.1.5 Edited: Williams, MG, 2011-08-12 Pubmed15944408 Pubmed19019078 Pubmed19501189 Pubmed20705608 Pubmed8083230 Reactome Database ID Release 431482685 Reactome, http://www.reactome.org ReactomeREACT_120985