1,25-dihydroxyvitamin D3 is deactivated Authored: Jassal, B, 2008-10-01 13:18:42 Calcitriol (1,25(OH)2-D3) is biologically inactivated through a series of reactions beginning with 24-hydroxylation and is most likely a mechanism of elimination. 24-Hydroxylation of the vitamin D metabolites is largely regulated inversely to 1-hydroxylation, the initial step towards activation. Edited: Jassal, B, 2008-06-02 10:50:11 Pubmed8506296 Reactome Database ID Release 43209765 Reactome, http://www.reactome.org ReactomeREACT_13667 Reviewed: D'Eustachio, P, 2008-05-28 08:30:54