Legumain degrades DBP Authored: Jassal, B, 2008-10-01 13:18:42 EC Number: 3.4.22 Edited: Jassal, B, 2008-06-02 10:50:11 Mammalian legumain (asparagine-specific endoprotease) is a subfamily of cysteine proteases with no homology to other known proteases and is found in a wide range of organisms from parasites to plants and animals. Legumain requires acidic conditions for its degradative activity and has strict specificity for cleavage with an asparagine residue in the P1 site. Cubilin, once released from the complex, cycles back to the cell surface. Calcidiol also becomes available for further processing. Pubmed11085925 Pubmed9821970 Reactome Database ID Release 43350158 Reactome, http://www.reactome.org ReactomeREACT_13664 Reviewed: D'Eustachio, P, 2008-05-28 08:30:54 Cubilin:DBP:Calcidiol