Cytosolic Hydroxylation of Asparagine Residue in HIF alpha Authored: May, B, 2011-03-18 EC Number: 1.14.11 Edited: May, B, 2011-03-18 HIF1AN (FIH, FIH-1) catalyzes the hydroxylation of an asparagine residue on each of HIF1A and HIF2A (Hewitson et al. 2002, Lando et al. 2002, Metzen et al. 2003, Lancaster et al. 2004). The reaction requires molecular oxygen as a substrate and is therefore inhibited by hypoxia. Pubmed12042299 Pubmed12080085 Pubmed12615973 Pubmed15239670 Reactome Database ID Release 431234164 Reactome, http://www.reactome.org ReactomeREACT_121198 Reviewed: Rantanen, Krista, 2012-05-19 hydroxyAsn-HIF1A/HIF2A HIF1A/HIF2A