Cytosolic Hydroxylation of Proline Residues on HIF1A Authored: May, B, 2011-03-09 Edited: May, B, 2011-03-09 Proline hydroxylases PHD2 (EGLN1) and PHD3 (EGLN3) located in the cytosol (Metzen et al. 2003) hydroxylate HIF1A at proline-402 and proline-564 (Bruick and McKnight 2001, Jaakkola et al. 2001, Ivan et al. 2001, Ivan et al. 2002, Berra et al. 2003, Hirsila et al. 2003, Appelhoff et al. 2004, Tuckerman et al. 2004, Fedulova et al. 2007, Tian et al. 2011). A portion of PHD3 (EGLN3) is also located in the nucleus (Rantanen et al. 2008). Pubmed11292861 Pubmed11292862 Pubmed11598268 Pubmed12351678 Pubmed12615973 Pubmed12788921 Pubmed12912907 Pubmed15247232 Pubmed15474027 Pubmed17434750 Pubmed18337469 Pubmed21335549 Reactome Database ID Release 431234177 Reactome, http://www.reactome.org ReactomeREACT_120825 Reviewed: Rantanen, Krista, 2012-05-19 has a Stoichiometric coefficient of 2