Cytosolic Hydroxylation of Proline Residues on HIF3A Authored: May, B, 2011-03-09 Edited: May, B, 2011-03-09 Proline hydroxylases PHD2 (EGLN1) and PHD3 (EGLN3) located in the cytosol (Metzen et al. 2003) hydroxylate HIF3A at proline-492 (Hirsila et al. 2003, Maynard et al. 2003). A portion of PHD3 (EGLN3) is also located in the nucleus (Rantanen et al. 2008). Pubmed12538644 Pubmed12615973 Pubmed12788921 Pubmed18337469 Reactome Database ID Release 431234173 Reactome, http://www.reactome.org ReactomeREACT_121242 Reviewed: Rantanen, Krista, 2012-05-19