Nuclear VHL:EloB/C:CUL2:RBX1 Complex Binds HIF-alpha Hydroxylated at Proline Residues Authored: May, B, 2011-03-09 Edited: May, B, 2011-03-09 Pubmed10823831 Pubmed10878807 Pubmed10944113 Pubmed11024059 Pubmed11292861 Pubmed11292862 Pubmed11358837 Pubmed11454738 Pubmed11504942 Pubmed12101228 Pubmed12821933 Pubmed9122164 Reactome Database ID Release 431234169 Reactome, http://www.reactome.org ReactomeREACT_120876 Reviewed: Rantanen, Krista, 2012-05-19 The VHL component of the VHL:ElonginB:ElonginC:CUL2:RBX1 binds HIF-alpha that have hydroxylated proline residues (Cockman et al. 2000, Ohh et al. 2000, Tanimoto et al. 2000, Jaakkola et al. 2001, Ivan et al. 2001, Yu et al. 2001, Bonicalzi et al. 2001). The VHL:HIF-alpha complex is predominantly nuclear (Lewis and Roberts 2003) however binding and degradation of HIF-alpha can also occur in the cytosol (Berra et al. 2001). hydroxyPro-HIF-alpha hydroxyPro-HIF-alpha:VHL:EloB/C:CUL2:RBX1 VHL:EloB/C:CUL2:RBX1