Nuclear Hydroxylation of Proline Residues on HIF3A Authored: May, B, 2011-03-09 Edited: May, B, 2011-03-09 Proline hydroxylases PHD1 (EGLN2) and PHD3 (EGLN3) located in the nucleus (Metzen et al. 2003) hydroxylate HIF3A at proline-492 (Hirsila et al. 2003, Maynard et al. 2003). Note that proline-492 of the reference isoform is proline-490 in isoform 2, the protein cited by Maynard et al. 2003. The amount of hydroxylation occurring in the nucleus is controversial. Most hydroxylation is believed to occur in the cytosol. Pubmed12538644 Pubmed12615973 Pubmed12788921 Reactome Database ID Release 431234165 Reactome, http://www.reactome.org ReactomeREACT_120945 Reviewed: Rantanen, Krista, 2012-05-19