Cytosolic VHL:EloB/C:CUL2:RBX1 Complex Binds HIF-alpha Hydroxylated at Proline Residues Authored: May, B, 2011-03-09 Edited: May, B, 2011-03-09 Pubmed10823831 Pubmed10878807 Pubmed10944113 Pubmed11292861 Pubmed11292862 Pubmed11358837 Pubmed11454738 Pubmed11504942 Pubmed12821933 Reactome Database ID Release 431234183 Reactome, http://www.reactome.org ReactomeREACT_120795 Reviewed: Rantanen, Krista, 2012-05-19 VHL within the VHL:ElonginB:ElonginC:CUL2:RBX1 Complex binds HIF-alpha subunits that have hydroxylated proline residues (Cockman et al. 2000, Ohh et al. 2000, Tanimoto et al. 2000, Jaakkola et al. 2001, Ivan et al. 2001, Yu et al. 2001). VHL constitutively shuttles between the cytosol and nucleoplasm (Lewis and Roberts 2003) and though the VHL:HIF-alpha complex is predominantly nuclear, binding and degradation can occur in both the cytosol and the nucleus (Berra et al. 2001). hydroxyPro-HIF-alpha RBX1-CUL2-EloB/C-VHL hydroxyPro-HIF-alpha:VHL:EloB/C:CUL2:RBX1