PI(3,5)P2 is dephosphorylated to PI3P by FIG4 at the early endosome membrane At the early endosome membrane, the PAS complex, consisting of FYVE finger-containing phosphoinositide kinase (PIKFYVE), yeast VAC14 homologue (VAC14), and polyphosphoinositide phosphatase aka SAC3 (FIG4), binds to the membrane via PIKFYVE's FYVE finger. The FIG4 phosphatase component dephosphorylates phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) to phosphatidylinositol 3-phosphate (PI3P) (Sbrissa et al. 2007, Sbrissa et al. 2008). Authored: Williams, MG, 2011-10-18 Edited: Williams, MG, 2011-08-12 Pubmed17556371 Pubmed18950639 Reactome Database ID Release 431676174 Reactome, http://www.reactome.org ReactomeREACT_121095 Reviewed: Wakelam, Michael, 2012-05-14