PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane At the plasma membrane, synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1 aka synaptojanin-1 (SYNJ1) (Guo et al. 1999, Mani et al. 2007) and -2 (SYNJ2) (Malecz et al. 2000) dephosphorylate phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) to phosphatidylinositol 3-phosphate (PI3P). Authored: Williams, MG, 2011-10-18 Edited: Williams, MG, 2011-08-12 Pubmed10224048 Pubmed11084340 Pubmed18093523 Reactome Database ID Release 431675836 Reactome, http://www.reactome.org ReactomeREACT_121103 Reviewed: Wakelam, Michael, 2012-05-14